Comfort Inn & Suites Greenville I-70

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Whether you're visiting the Upstate region on business or just for fun, you’ll love the cozy accommodations, friendly service and convenient amenities at our pet-friendly hotel in Greenville. At our Comfort Inn & Suites® hotel, we do our best to help you feel refreshed and ready to take on whatever the day brings, and that means premium beds for a restful night's sleep and more. We know location is important to you, and you'll find out hotel right off of Interstate 70 near the American Farm Heritage Museum and Bond County Fairground, with Greenville Airport just 3 miles south along Route 127. Head downtown to visit Greenville University or to explore the surrounding museums that feature everything from sculptures to a preserved 1840s house to the unique creations of the local DeMoulin Bros. & Co. factory. You can also watch a game or go for a run on the track at nearby John Strahl Athletic Complex. When it's time to unwind, return to the hotel to settle in for a relaxing night in. Kick back with a movie on your room's flat-screen TV, tend to late-night emails on the work desk, or simply tuck yourself into our plush bedding for some well-deserved rest.

Edwardsville